IQANsimulate 5.03.11.5029 error: Measure terminated (no valid application in target module)

We have an application that was developed in IQANdesign 5.03.11.5029 but when we try to run the simulation we have the following error displayed and the MD4-10 is blank;

The system has approximately 8 arrays each sized for 2000 samples... if we reduce the sample side of each to < 950 samples, the simulation will run normally?!  Has anyone else experienced this?